Rat TRPM4 (Transient Receptor Potential Cation Channel Subfamily M, Member 4) Sandwich ELISA Kit Ready-To-Use Kit (STJE0019206)
SPECIFICATIONS
General Information
| Short Description | This TRPM4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Rat |
| Sensitivity | 0.055ng/mL |
| Detection Limit | 0.156-10ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20Β°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8Β°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | Trpm4 |
| Gene ID | 171143 |
| Uniprot ID | TRPM4_RAT |
| Immunogen Region | Ready-To-Use |
| Sample Type | tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Isoform 1 is highly expressed in the testis with a moderate expression in the brain, spleen and thymus. Isoform 2 is only expressed in the brain and spleen. |
| Post Translational Modifications | Phosphorylation by PKC leads to increase the sensitivity to Ca(2+). Sumoylated. Desumoylated by SENP1. |
| Function | Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation. Isoform 2: Lacks channel activity. |
| Protein Name | Transient Receptor Potential Cation Channel Subfamily M Member 4Calcium-Activated Non-Selective Cation Channel 1Long Transient Receptor Potential Channel 4Ltrpc-4Ltrpc4Mls2sMelastatin-Like 2 |
| Database Links | Reactome: R-RNO-3295583 |
| Cellular Localisation | Isoform 1: Cell MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumGolgi ApparatusIsoform 2: Cell MembraneMainly Integrated Into The Er/Golgi Complex And Is Rarely Found In The Plasma Membrane |
| Alternative ELISA Names | Transient Receptor Potential Cation Channel Subfamily M Member 4 ELISA kitCalcium-Activated Non-Selective Cation Channel 1 ELISA kitLong Transient Receptor Potential Channel 4 ELISA kitLtrpc-4 ELISA kitLtrpc4 ELISA kitMls2s ELISA kitMelastatin-Like 2 ELISA kitTrpm4 ELISA kitLtrpc4 ELISA kit |
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Information sourced from Uniprot.org