This TRPM4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates or other biological fluids..
Applications
ELISA
Reactivity
Rat
Sensitivity
0.055ng/mL
Detection Limit
0.156-10ng/mL
Note
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Product Properties
Storage Instruction
The whole kit may be stored at-20Β°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8Β°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Isoform 1 is highly expressed in the testis with a moderate expression in the brain, spleen and thymus. Isoform 2 is only expressed in the brain and spleen.
Post Translational Modifications
Phosphorylation by PKC leads to increase the sensitivity to Ca(2+). Sumoylated. Desumoylated by SENP1.
Function
Calcium-activated selective cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway. Plays a role in keratinocyte differentiation. Isoform 2: Lacks channel activity.
Protein Name
Transient Receptor Potential Cation Channel Subfamily M Member 4Calcium-Activated Non-Selective Cation Channel 1Long Transient Receptor Potential Channel 4Ltrpc-4Ltrpc4Mls2sMelastatin-Like 2
Isoform 1: Cell MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumGolgi ApparatusIsoform 2: Cell MembraneMainly Integrated Into The Er/Golgi Complex And Is Rarely Found In The Plasma Membrane
