Rat ENK (Enkephalin) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015027)

Rat ENK (Enkephalin) Sandwich ELISA Kit Ready-To-Use Kit (STJE0015027)

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STJE0015027
€544.20 - €757.80
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Short Description :This ENK Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat serum, plasma or other biological fluids..
Applications:ELISA
Reactivity:Rat
Sensitivity:25.13pg/mL
Detection Limit:93.7-6000pg/mL
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Storage Instruction:The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time:3 hrs
Gene Symbol:Penk
Gene ID:29237
Uniprot ID:PENK_RAT
Immunogen Region:Ready-To-Use
Sample Type:serum, plasma or other biological fluids.
Tissue Specificity Expressed in brain, heart and testis.
Post Translational Modifications Proenkephalin-A is cleaved by CTSL to generate Met-enkephalin. Met-enkephalin: Processed and degraded by ACE. Leu-enkephalin: Processed and degraded by ACE. Met-enkephalin-Arg-Gly-Leu: Probably cleaved by ACE. Met-enkephalin-Arg-Phe: Processed by ACE to generate Met-enkephalin in the nucleus accumbens of the brain. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Function Met-enkephalin: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Leu-enkephalin: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Met-enkephalin-Arg-Phe: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release. PENK(114-133): Increases glutamate release in the striatum and decreases GABA concentration in the striatum. PENK(239-260): Increases glutamate release in the striatum.
Protein Name Proenkephalin-A Cleaved Into - Synenkephalin - Met-Enkephalin
Opioid Growth Factor
Ogf - Penk(114-133 - Penk(143-185 - Met-Enkephalin-Arg-Gly-Leu - Leu-Enkephalin - Penk(239-260 - Met-Enkephalin-Arg-Phe
Database Links Reactome: R-RNO-375276
Reactome: -RNO-381426
Reactome: -RNO-418594
Reactome: -RNO-8957275
Cellular Localisation Secreted
Cytoplasmic Vesicle
Secretory Vesicle
Chromaffin Granule Lumen
Alternative ELISA Names Proenkephalin-A Cleaved Into - Synenkephalin - Met-Enkephalin ELISA kit
Opioid Growth Factor ELISA kit
Ogf - Penk(114-133 - Penk(143-185 - Met-Enkephalin-Arg-Gly-Leu - Leu-Enkephalin - Penk(239-260 - Met-Enkephalin-Arg-Phe ELISA kit
Penk ELISA kit
Penk-rs ELISA kit
Penk1 ELISA kit
output

Information sourced from Uniprot.org

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