| Tissue Specificity | Detected in macrophages and peripheral blood monocytes. |
| Post Translational Modifications | |
| Function | Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). |
| Protein Name | Monocyte Differentiation Antigen Cd14Myeloid Cell-Specific Leucine-Rich GlycoproteinCd Antigen Cd14 |
| Database Links | Reactome: R-RNO-140534Reactome: -RNO-166016Reactome: -RNO-166020Reactome: -RNO-166166Reactome: -RNO-2562578Reactome: -RNO-5686938Reactome: -RNO-6798695Reactome: -RNO-936964Reactome: -RNO-937041Reactome: -RNO-937072Reactome: -RNO-975163Reactome: -RNO-9824878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedMembrane RaftGolgi ApparatusSolubleSecreted Forms Seem To ExistThey May Arise By Cleavage Of The Gpi Anchor |
| Alternative ELISA Names | Monocyte Differentiation Antigen Cd14 ELISA kitMyeloid Cell-Specific Leucine-Rich Glycoprotein ELISA kitCd Antigen Cd14 ELISA kitCd14 ELISA kit |
| output | |
Information sourced from Uniprot.org
