| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.51ng/mL |
| Detection Limit: | 1.56-100ng/mL |
| Short Description: | This CD14 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | Cd14 |
| Gene ID: | 60350 |
| Uniprot ID: | CD14_RAT |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | Detected in macrophages and peripheral blood monocytes. |
| Post Translational Modifications | |
| Function | Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-). |
| Protein Name | Monocyte Differentiation Antigen Cd14 Myeloid Cell-Specific Leucine-Rich Glycoprotein Cd Antigen Cd14 |
| Database Links | Reactome: R-RNO-140534 Reactome: -RNO-166016 Reactome: -RNO-166020 Reactome: -RNO-166166 Reactome: -RNO-2562578 Reactome: -RNO-5686938 Reactome: -RNO-6798695 Reactome: -RNO-936964 Reactome: -RNO-937041 Reactome: -RNO-937072 Reactome: -RNO-975163 Reactome: -RNO-9824878 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Secreted Membrane Raft Golgi Apparatus Soluble Secreted Forms Seem To Exist They May Arise By Cleavage Of The Gpi Anchor |
| Alternative ELISA Names | Monocyte Differentiation Antigen Cd14 ELISA kit Myeloid Cell-Specific Leucine-Rich Glycoprotein ELISA kit Cd Antigen Cd14 ELISA kit Cd14 ELISA kit |
| output |
Information sourced from Uniprot.org
