• Rat c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP001962)
  • Rat c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP001962)

Rat c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP001962)

SKU:
STJP001962

Current Stock:
Host: HEK293 cells
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Rat c-Kit ligand/SCF/KITLG-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Measured in a cell proliferation assay using MC/9‑2 mouse mast cells.The ED50 for this effect is 9.95-39.78 ng/mL, corresponding to a specific activity of 2.51×104~ 1.01× 10 5 units/mg.
Gene Symbol: Kitlg
Gene ID: 60427
Uniprot ID: SCF_RAT
Immunogen Region: Gln26-Ala189
Immunogen: Recombinant Rat c-Kit ligand/SCF/KITLG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln26-Ala189) of rat c-Kit ligand/SCF/KITLG (Accession #NP_068615.1) fused with 6×His tag at the C-terminus.
Function Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Protein Name Kit Ligand
Hematopoietic Growth Factor Kl
Mast Cell Growth Factor
Mgf
Stem Cell Factor
Scf
C-Kit Ligand Cleaved Into - Soluble Kit Ligand
Skitlg
Database Links Reactome: R-RNO-1257604
Reactome: -RNO-1433557
Reactome: -RNO-1433559
Reactome: -RNO-5673001
Reactome: -RNO-6811558
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform 2: Cytoplasm
Cytoplasm
Cytoskeleton
Cell Membrane
Cell Projection
Lamellipodium
Filopodium
Soluble Kit Ligand: Secreted
Alternative Protein Names Kit Ligand protein
Hematopoietic Growth Factor Kl protein
Mast Cell Growth Factor protein
Mgf protein
Stem Cell Factor protein
Scf protein
C-Kit Ligand Cleaved Into - Soluble Kit Ligand protein
Skitlg protein
Kitlg protein
Kitl protein
Mgf protein

Information sourced from Uniprot.org

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