Name: Rat c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP001962)
SKU: STJP001962
Availability: InStock

General Information
Product Properties
Target Information
Additional Info
Product Review

Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 0.01 EU/Mu g
Immunoreactivity:	Measured in a cell proliferation assay using MC/9‑2 mouse mast cells.The ED50 for this effect is 9.95-39.78 ng/mL, corresponding to a specific activity of 2.51×10⁴~ 1.01× 10 ⁵ units/mg.

Gene Symbol:	Kitlg
Gene ID:	60427
Uniprot ID:	SCF_RAT
Immunogen Region:	Gln26-Ala189
Immunogen:	Recombinant Rat c-Kit ligand/SCF/KITLG Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln26-Ala189) of rat c-Kit ligand/SCF/KITLG (Accession #NP_068615.1) fused with 6×His tag at the C-terminus.
Immunogen Sequence:	QEICRNPVTDNVKDITKLVA NLPNDYMITLNYVAGMDVLP SHCWLRDMVTHLSVSLTTLL DKFSNISEGLSNYSIIDKLG KIVDDLVACMEENAPKNVKE SLKKPETRNFTPEEFFSIFN RSIDAFKDFMVASDTSDCVL SSTLGPEKDSRVSVTKPFML PPVA

Function	Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Protein Name	Kit Ligand Hematopoietic Growth Factor Kl Mast Cell Growth Factor Mgf Stem Cell Factor Scf C-Kit Ligand Cleaved Into - Soluble Kit Ligand Skitlg
Database Links	Reactome: R-RNO-1257604 Reactome: -RNO-1433557 Reactome: -RNO-1433559 Reactome: -RNO-5673001 Reactome: -RNO-6811558 Reactome: -RNO-9856649
Cellular Localisation	Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cytoplasm Cytoplasm Cytoskeleton Cell Membrane Cell Projection Lamellipodium Filopodium Soluble Kit Ligand: Secreted
Alternative Protein Names	Kit Ligand protein Hematopoietic Growth Factor Kl protein Mast Cell Growth Factor protein Mgf protein Stem Cell Factor protein Scf protein C-Kit Ligand Cleaved Into - Soluble Kit Ligand protein Skitlg protein Kitlg protein Kitl protein Mgf protein

Information sourced from Uniprot.org

Model	Name	Host
STJP002693	Mouse c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP002693)	HEK293 cells
STJP002574	Human c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP002574)	HEK293 cells
STJP002723	Human Flt4 ligand/VEGF-C protein (Recombinant) (C-His) (STJP002723)	HEK293 cells
STJP001149	Rat C-Reactive/CRP protein (Recombinant) (C-His) (STJP001149)	HEK293 cells
STJP002434	Mouse/Rat VEGF-C protein (Recombinant) (C-His) (STJP002434)	HEK293 cells

Rat c-Kit ligand/SCF/KITLG protein (Recombinant) (C-His) (STJP001962)

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