| Tissue Specificity | |
| Post Translational Modifications | ISGylated. |
| Function | Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Binds to endosomes damaged by phagocytosis of particulate wear debris and participates in endosomal membrane stabilization, thereby limiting NLRP3 inflammasome activation. Required for endothelial cell surface plasmin generation and may support fibrinolytic surveillance and neoangiogenesis. |
| Protein Name | Annexin A2Annexin IiAnnexin-2Calpactin I Heavy ChainCalpactin-1 Heavy ChainChromobindin-8Lipocortin IiPlacental Anticoagulant Protein IvPap-IvProtein IP36 |
| Database Links | Reactome: R-RNO-6798695Reactome: -RNO-75205Reactome: -RNO-9860927 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixBasement MembraneMelanosomeIn The Lamina Beneath The Plasma Membrane |
| Alternative ELISA Names | Annexin A2 ELISA kitAnnexin Ii ELISA kitAnnexin-2 ELISA kitCalpactin I Heavy Chain ELISA kitCalpactin-1 Heavy Chain ELISA kitChromobindin-8 ELISA kitLipocortin Ii ELISA kitPlacental Anticoagulant Protein Iv ELISA kitPap-Iv ELISA kitProtein I ELISA kitP36 ELISA kitAnxa2 ELISA kitAnx2 ELISA kit |
| output | |
Information sourced from Uniprot.org
