Rabbit Monoclonal Antibodies
Over 7,600 rabbit monoclonal antibodies validated across Western blot, IHC, immunofluorescence, flow cytometry and ELISA. Rabbit-derived monoclonals recognise a broader range of epitopes than mouse clones, including epitopes that are non-immunogenic in rodents, making them well suited for detecting low-abundance targets and post-translational modifications.
Browse Rabbit Monoclonal AntibodiesWhy Choose Rabbit Monoclonal Antibodies
Rabbit monoclonal antibodies were first developed and optimised in the 1990s. Their distinct immune biology gives them several measurable advantages over mouse monoclonal antibodies in demanding research applications.
Broader Epitope Coverage
Rabbits generate a more diverse antibody repertoire through somatic gene conversion and hypermutation. They recognise a wider range of epitopes, including those poorly immunogenic in rodents, and exhibit reduced immunodominance — resulting in antibody responses against multiple non-dominant regions of an antigen. This makes rabbit monoclonals particularly effective for detecting conserved human proteins.
Performance Characteristics
- Higher affinity binding to human antigen targets, including low-abundance proteins
- Reduced cross-reactivity with endogenous mouse antigens — lower background in mouse tissue models
- Superior signal-to-noise ratio in IHC and immunofluorescence applications
- Compatible with dual staining alongside mouse monoclonal antibodies on the same tissue section
- Robust performance in formalin-fixed paraffin-embedded (FFPE) tissue with minimal pre-treatment
Post-Translational Modification Detection
Post-translational modifications (PTMs) alter protein structure, stability, localisation and function. Rabbit monoclonals are effective at recognising the small, structurally distinct epitopes created by phosphorylation, methylation, acetylation and sumoylation — modifications that are difficult to target reliably with mouse clones.
Immunohistochemistry in Paraffin-Embedded Tissue
Rabbit monoclonal antibodies offer increased sensitivity at higher working dilutions in IHC, reducing reagent cost while maintaining specificity. The format is compatible with FFPE tissue and supports dual staining alongside mouse monoclonal antibodies on the same section. Targets below include proliferation markers, oncology markers and immune context markers validated in paraffin tissue.
IHC Guaranteed Range
Selected rabbit monoclonal antibodies are part of the IHC Guaranteed range, validated in formalin-fixed paraffin-embedded tissue sections with representative images and dilution data in every datasheet. Browse the full IHC Guaranteed range →
Single-Cell Analysis by Flow Cytometry
Rabbit monoclonal antibodies for flow cytometry are available conjugated to FITC, PE, APC, PerCP and tandem dye variants. The range covers key immune cell surface markers and intracellular targets including activation markers, immune checkpoints and co-stimulatory molecules, supporting multi-colour panel design for immunophenotyping studies.
Phosphoprotein Detection by Western Blot
Phospho-specific rabbit monoclonal antibodies detect activated kinase signalling at defined residues, enabling site-specific analysis of pathway activity. The range includes phospho-AKT isoforms at multiple sites (T308, S473, T450, S129) and phospho-ERK1/2 at T202/Y204 and T185/Y187, alongside total protein antibodies for normalisation.
Epithelial Integrity & Organelle Markers for Immunofluorescence
Rabbit monoclonal antibodies for immunofluorescence staining of junction proteins, cytoskeletal markers and organelle-resident proteins in fixed cell models. Targets include adherens junction components (E-cadherin, beta-catenin), tight junction proteins (ZO-1, Claudin-1), cytokeratin isoforms and the Golgi matrix protein GM130.
Soluble Protein Quantification by ELISA
Rabbit monoclonal antibodies for ELISA applications targeting inflammation markers, extracellular matrix regulators and haemostasis proteins. Each antibody has been tested for performance in sandwich and direct ELISA formats. Refer to individual datasheets for confirmed dilutions and working concentrations.
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Browse the Full Rabbit Monoclonal Range
Over 7,600 rabbit monoclonal antibodies validated across WB, IHC, IF, Flow and ELISA. Filter by application, target or research area to find the right antibody for your experiment.
Browse Rabbit Monoclonal Antibodies