Tissue Specificity | Widely expressed. Highly expressed in testis, heart and pancreas. Detected at lower levels in kidney, skeletal muscle, brain, placenta, lung and liver. |
Function | Transfers mannosyl residues to the hydroxyl group of serine or threonine residues. Coexpression of both POMT1 and POMT2 is necessary for enzyme activity, expression of either POMT1 or POMT2 alone is insufficient. Essentially dedicated to O-mannosylation of alpha-DAG1 and few other proteins but not of cadherins and protocaherins. |
Peptide Name | Protein O-Mannosyl-Transferase 1Dolichyl-Phosphate-Mannose--Protein Mannosyltransferase 1 |
Database Links | Reactome: R-HSA-5083629Reactome: R-HSA-5083633Reactome: R-HSA-5173105 |
Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
Alternative Peptide Names | Protein O-Mannosyl-Transferase 1 proteinDolichyl-Phosphate-Mannose--Protein Mannosyltransferase 1 proteinPOMT1 protein |
Information sourced from Uniprot.org