| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PGCF Blocking Peptide for STJ502470 is synthetically produced from the C-Term sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Gucy2f |
| Gene ID: |
116556 |
| Uniprot ID: |
GUC2F_RAT |
| Immunogen Region: |
C-Term |
| Specificity: |
This blocking peptide is recommended for use in combination with PGCF antibody, STJ502470 |
| Immunogen: |
Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase F protein. |
| Tissue Specificity | Expressed only in the eye. |
| Post Translational Modifications | There are 9 conserved cysteine residues in sensory guanylate cyclases, 6 in the extracellular domain, which may be involved in intra- or interchain disulfide bonds. |
| Function | Responsible for the synthesis of cyclic GMP (cGMP) in rods and cones of photoreceptors. Plays an essential role in phototransduction, by mediating cGMP replenishment. May also participate in the trafficking of membrane-asociated proteins to the photoreceptor outer segment membrane. |
| Peptide Name | Retinal Guanylyl Cyclase 2Retgc-2Guanylate Cyclase 2f - RetinalGuanylate Cyclase FGc-FRod Outer Segment Membrane Guanylate Cyclase 2Ros-Gc2 |
| Database Links | Reactome: R-RNO-2514859 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinPhotoreceptor Outer Segment Membrane |
| Alternative Peptide Names | Retinal Guanylyl Cyclase 2 proteinRetgc-2 proteinGuanylate Cyclase 2f - Retinal proteinGuanylate Cyclase F proteinGc-F proteinRod Outer Segment Membrane Guanylate Cyclase 2 proteinRos-Gc2 proteinGucy2f proteinGuc2f protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
