| Tissue Specificity | Specifically expressed in a subpopulation of olfactory sensory neurons. Expressed in the cilia of the olfactory epithelium. |
| Function | Functions as an olfactory receptor activated by a urine odorant, uroguanylin. Activated as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2). Has guanylate cyclase activity upon binding of the ligand. Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency. Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference. |
| Peptide Name | Guanylate Cyclase 2dGuanylate Cyclase - OlfactoryOne-GcOlfactory Guanylyl Cyclase Gc-DGc-D |
| Cellular Localisation | Cell ProjectionCilium MembraneSingle-Pass Type I Membrane ProteinColocalized With Ncald At The Apical Region Of The CiliaCoexpresses With Pde2 |
| Alternative Peptide Names | Guanylate Cyclase 2d proteinGuanylate Cyclase - Olfactory proteinOne-Gc proteinOlfactory Guanylyl Cyclase Gc-D proteinGc-D proteinGucy2d proteinGucy2e protein |
Information sourced from Uniprot.org
