| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | PACAP Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:2, 500-1:5, 000 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | ADCYAP1 |
| Gene ID: | 116 |
| Uniprot ID: | PACA_HUMAN |
| Immunogen: | Purfied protein. |
| Function | Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway. In chromaffin cells, induces long-lasting increase of intracellular calcium concentrations and neuroendocrine secretion. Involved in the control of glucose homeostasis, induces insulin secretion by pancreatic beta cells. |
| Peptide Name | Pituitary Adenylate Cyclase-Activating Polypeptide Pacap Cleaved Into - Pacap-Related Peptide Prp-48 - Pituitary Adenylate Cyclase-Activating Polypeptide 27 Pacap-27 Pacap27 - Pituitary Adenylate Cyclase-Activating Polypeptide 38 Pacap-38 Pacap38 |
| Database Links | Reactome: R-HSA-187024 Reactome: R-HSA-418555 Reactome: R-HSA-420092 |
| Cellular Localisation | Secreted |
| Alternative Peptide Names | Pituitary Adenylate Cyclase-Activating Polypeptide protein Pacap Cleaved Into - Pacap-Related Peptide protein Prp-48 - Pituitary Adenylate Cyclase-Activating Polypeptide 27 protein Pacap-27 protein Pacap27 - Pituitary Adenylate Cyclase-Activating Polypeptide 38 protein Pacap-38 protein Pacap38 protein ADCYAP1 protein |
Information sourced from Uniprot.org