• Mouse Vitronectin/V75/VTN protein (Recombinant) (C-His) (STJP002440)

Mouse Vitronectin/V75/VTN protein (Recombinant) (C-His) (STJP002440)

SKU:
STJP002440

£55.50 - £190.50
Current Stock:
Host: HEK293 Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <1 EU/Mu g
Immunoreactivity: Measured by the ability of the immobilized protein to support the adhesion of B16‑F1 mouse melanoma cells. When 5×104 cells/well are added to Vitronectin coated plates (5 µg/mL with 100 µL/well) , approximately >80% will adhere after 30 mi
Gene Symbol: Vtn
Gene ID: 22370
Uniprot ID: VTNC_MOUSE
Immunogen Region: Asp20-Lys478
Immunogen: Recombinant Mouse Vitronectin/V75/VTN Protein is produced by HEK293 Cells expression system. The target protein is expressed with sequence (Asp20-Lys478) of mouse Vitronectin/V75/VTN (Accession #NP_035837.1) fused with a 6×His tag at the C-terminus.
Immunogen Sequence: DQESCKGRCTQGFMASKKCQ CDELCTYYQSCCADYMEQCK PQVTRGDVFTMPEDDYWSYD YVEEPKNNTNTGVQPENTSP PGDLNPRTDGTLKPTAFLDP EEQPSTPAPKVEQQEEILRP DTTDQGTPEFPEEELCSGKP FDAFTDLKNGSLFAFRGQYC YELDETAVRPGYPKLIQDVW GIEGPIDAAFTRINCQGKTY LFKGSQYWRFEDGVLDPGYP RNISEGFSGIPDNVDAAFA
Post Translational Modifications Sulfated on tyrosine residues. N- and O-glycosylated. It has been suggested that the active SMB domain may be permitted considerable disulfide bond heterogeneity or variability, thus two alternate disulfide patterns based on 3D structures are described with 1 disulfide bond conserved in both.
Function Vitronectin is a cell adhesion and spreading factor found in serum and tissues. Vitronectin interact with glycosaminoglycans and proteoglycans. Is recognized by certain members of the integrin family and serves as a cell-to-substrate adhesion molecule. Inhibitor of the membrane-damaging effect of the terminal cytolytic complement pathway.
Protein Name Vitronectin
Vn
S-Protein
Serum-Spreading Factor
Database Links Reactome: R-MMU-2129379
Reactome: -MMU-216083
Reactome: -MMU-3000170
Reactome: -MMU-3000178
Reactome: -MMU-977606
Cellular Localisation Secreted
Extracellular Space
Alternative Protein Names Vitronectin protein
Vn protein
S-Protein protein
Serum-Spreading Factor protein
Vtn protein

Information sourced from Uniprot.org

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