| Tissue Specificity | Expressed in the outer plexiform layer of the retina (at protein level). |
| Post Translational Modifications | Phosphorylated by PRKCZ in vitro and this phosphorylation is increased in the presence of WDFY2. (Microbial infection) Targeted and hydrolyzed by C.botulinum neurotoxin type B (BoNT/B, botB).20 hours after treatment of spinal cord cells almost all the protein has been digested. BoNT/B hydrolyzes the 76-Gln-|-Phe-77 bond and inhibits neurotransmitter release (Probable). (Microbial infection) Targeted and hydrolyzed by C.tetani toxin (tetX).20 hours after treatment of spinal cord cells almost all the protein has been digested. Tetanus toxin hydrolyzes the 76-Gln-|-Phe-77 bond and inhibits neurotransmitter release (Probable). |
| Function | Involved in the targeting and/or fusion of transport vesicles to their target membrane. Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. |
| Protein Name | Vesicle-Associated Membrane Protein 2Vamp-2Synaptobrevin-2 |
| Database Links | Reactome: R-MMU-181429Reactome: -MMU-181430Reactome: -MMU-199992Reactome: -MMU-210500Reactome: -MMU-212676Reactome: -MMU-264642Reactome: -MMU-432720Reactome: -MMU-432722Reactome: -MMU-449836Reactome: -MMU-8856825Reactome: -MMU-8856828Reactome: -MMU-888590Reactome: -MMU-9609523 |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleSynaptic Vesicle MembraneSingle-Pass Type Iv Membrane ProteinCell MembraneColocalizes With Prkcz And Wdfy2 In Intracellular Vesicles |
| Alternative Protein Names | Vesicle-Associated Membrane Protein 2 proteinVamp-2 proteinSynaptobrevin-2 proteinVamp2 proteinSyb2 protein |
Information sourced from Uniprot.org
