| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its binding ability in a functional ELISA. Immobilized Recombinant Mouse TNFR1 at 2 Mu g/mL (100 Mu L/well) can bind Recombinant Mouse TNF-alpha with a linear range of 0.096-4.5 ng/mL. |
| Gene Symbol: | Tnfrsf1a |
| Gene ID: | 21937 |
| Uniprot ID: | TNR1A_MOUSE |
| Immunogen Region: | Met1-Ala212 |
| Immunogen: | Recombinant Mouse TNFRSF1A/TNF-R1/CD120a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Ala212) of mouse TNFR1/CD120a/TNFRSF1A (Accession #NP_035739.2) fused with a 6×His tag at the C-termin |
| Immunogen Sequence: | MGLPTVPGLLLSLVLLALLM GIHPSGVTGLVPSLGDREKR DSLCPQGKYVHSKNNSICCT KCHKGTYLVSDCPSPGRDTV CRECEKGTFTASQNYLRQCL SCKTCRKEMSQVEISPCQAD KDTVCGCKENQFQRYLSETH FQCVDCSPCFNGTVTIPCKE TQNTVCNCHAGFFLRESECV PCSHCKKNEECMKLCLPPPL ANVTNPQDSGTA |
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1aTumor Necrosis Factor Receptor 1Tnf-R1Tumor Necrosis Factor Receptor Type ITnf-RiTnfr-IP55P60Cd Antigen Cd120a |
| Database Links | Reactome: R-MMU-5357786Reactome: -MMU-5357905Reactome: -MMU-5357956Reactome: -MMU-5626978Reactome: -MMU-5669034Reactome: -MMU-75893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi Apparatus Membrane |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 1a proteinTumor Necrosis Factor Receptor 1 proteinTnf-R1 proteinTumor Necrosis Factor Receptor Type I proteinTnf-Ri proteinTnfr-I proteinP55 proteinP60 proteinCd Antigen Cd120a proteinTnfrsf1a proteinTnfr-1 proteinTnfr1 protein |
Information sourced from Uniprot.org
