• Human TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-hFc) (STJP001404)
  • Human TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-hFc) (STJP001404)
  • Human TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-hFc) (STJP001404)
  • Human TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-hFc) (STJP001404)
  • Human TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-hFc) (STJP001404)
  • Human TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-hFc) (STJP001404)

Human TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-hFc) (STJP001404)

SKU:
STJP001404

Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human TNFRSF1A/TNF-R1/CD120a-C-hFc protein was developed from hek293 cells and has a target region of C-hFc. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Mouse TNF Alpha at 2 Mu g/mL (100 Mu L/well) can bind Human TNFRSF1A with a linear range of 4-53 ng/mL.2. Measured by its ability to inhibit TNF-Alpha mediated cytotoxicity in L-929 m
Gene Symbol: TNFRSF1A
Gene ID: 7132
Uniprot ID: TNR1A_HUMAN
Immunogen: Recombinant Human TNFRSF1A/TNF-R1/CD120a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu30-Thr211) of human CD120a/TNFRSF1A (Accession #NP_001056.1) fused with a hFc tag at the C-terminus.
Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 1a
Tumor Necrosis Factor Receptor 1
Tnf-R1
Tumor Necrosis Factor Receptor Type I
Tnf-Ri
Tnfr-I
P55
P60
Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1
Tbpi
Database Links Reactome: R-HSA-5357786
Reactome: R-HSA-5357905
Reactome: R-HSA-5357956
Reactome: R-HSA-5626978
Reactome: R-HSA-5669034
Reactome: R-HSA-6783783
Reactome: R-HSA-75893
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus Membrane
Secreted
A Secreted Form Is Produced Through Proteolytic Processing
Isoform 4: Secreted
Lacks A Golgi-Retention Motif
Is Not Membrane Bound And Therefore Is Secreted
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 1a protein
Tumor Necrosis Factor Receptor 1 protein
Tnf-R1 protein
Tumor Necrosis Factor Receptor Type I protein
Tnf-Ri protein
Tnfr-I protein
P55 protein
P60 protein
Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 protein
Tbpi protein
TNFRSF1A protein
TNFAR protein
TNFR1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance