| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | 1.Measured by its binding ability in a functional ELISA. Immobilized Mouse TNF-alpha Protein at 0.5 Mu g/mL (100 Mu L/well) can bind Mouse TNFR1 with a linear range of 0.06-15.7 ng/mL.|2.Measured by its ability to inhibit the TNF Alpha-mediated cytot |
| Gene Symbol: | Tnfrsf1a |
| Gene ID: | 21937 |
| Uniprot ID: | TNR1A_MOUSE |
| Immunogen Region: | Met1-Ala212 |
| Immunogen: | Recombinant Mouse TNFRSF1A/TNF-R1/CD120a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Ala212) of mouse TNFR1/CD120a/TNFRSF1A (Accession #NP_035739.2) fused with an Fc, 6×His tag at the C-t |
| Immunogen Sequence: | MGLPTVPGLLLSLVLLALLM GIHPSGVTGLVPSLGDREKR DSLCPQGKYVHSKNNSICCT KCHKGTYLVSDCPSPGRDTV CRECEKGTFTASQNYLRQCL SCKTCRKEMSQVEISPCQAD KDTVCGCKENQFQRYLSETH FQCVDCSPCFNGTVTIPCKE TQNTVCNCHAGFFLRESECV PCSHCKKNEECMKLCLPPPL ANVTNPQDSGTA |
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1a Tumor Necrosis Factor Receptor 1 Tnf-R1 Tumor Necrosis Factor Receptor Type I Tnf-Ri Tnfr-I P55 P60 Cd Antigen Cd120a |
| Database Links | Reactome: R-MMU-5357786 Reactome: -MMU-5357905 Reactome: -MMU-5357956 Reactome: -MMU-5626978 Reactome: -MMU-5669034 Reactome: -MMU-75893 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Golgi Apparatus Membrane |
| Alternative Protein Names | Tumor Necrosis Factor Receptor Superfamily Member 1a protein Tumor Necrosis Factor Receptor 1 protein Tnf-R1 protein Tumor Necrosis Factor Receptor Type I protein Tnf-Ri protein Tnfr-I protein P55 protein P60 protein Cd Antigen Cd120a protein Tnfrsf1a protein Tnfr-1 protein Tnfr1 protein |
Information sourced from Uniprot.org