Mouse TNFRSF1A/TNF-R1/CD120a protein (Recombinant) (C-hFc & His) (STJP002696)

SKU:
STJP002696

£97.50 - £291.50
Current Stock:
Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Immunoreactivity: 1.Measured by its binding ability in a functional ELISA. Immobilized Mouse TNF-alpha Protein at 0.5 Mu g/mL (100 Mu L/well) can bind Mouse TNFR1 with a linear range of 0.06-15.7 ng/mL.|2.Measured by its ability to inhibit the TNF Alpha-mediated cytot
Gene Symbol: Tnfrsf1a
Gene ID: 21937
Uniprot ID: TNR1A_MOUSE
Immunogen Region: Met1-Ala212
Immunogen: Recombinant Mouse TNFRSF1A/TNF-R1/CD120a Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Ala212) of mouse TNFR1/CD120a/TNFRSF1A (Accession #NP_035739.2) fused with an Fc, 6×His tag at the C-t
Immunogen Sequence: MGLPTVPGLLLSLVLLALLM GIHPSGVTGLVPSLGDREKR DSLCPQGKYVHSKNNSICCT KCHKGTYLVSDCPSPGRDTV CRECEKGTFTASQNYLRQCL SCKTCRKEMSQVEISPCQAD KDTVCGCKENQFQRYLSETH FQCVDCSPCFNGTVTIPCKE TQNTVCNCHAGFFLRESECV PCSHCKKNEECMKLCLPPPL ANVTNPQDSGTA
Function Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 1a
Tumor Necrosis Factor Receptor 1
Tnf-R1
Tumor Necrosis Factor Receptor Type I
Tnf-Ri
Tnfr-I
P55
P60
Cd Antigen Cd120a
Database Links Reactome: R-MMU-5357786
Reactome: -MMU-5357905
Reactome: -MMU-5357956
Reactome: -MMU-5626978
Reactome: -MMU-5669034
Reactome: -MMU-75893
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Golgi Apparatus Membrane
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 1a protein
Tumor Necrosis Factor Receptor 1 protein
Tnf-R1 protein
Tumor Necrosis Factor Receptor Type I protein
Tnf-Ri protein
Tnfr-I protein
P55 protein
P60 protein
Cd Antigen Cd120a protein
Tnfrsf1a protein
Tnfr-1 protein
Tnfr1 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance