| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Immunoreactivity: | Measured in a cell proliferation assay using MO7e human megakaryocytic leukemic cells. Avanzi, G. et al. (1988) Br. J. Haematol. 69:359. The ED50 for this effect is 0.45-1.80 ng/mL. |
| Gene Symbol: | Thpo |
| Gene ID: | 21832 |
| Uniprot ID: | TPO_MOUSE |
| Immunogen Region: | Ser22-Thr356 |
| Immunogen: | Recombinant Mouse Thrombopoietin/THPO Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser22-Thr356) of mouse Thrombopoietin/THPO (Accession #NP_033405.1.) fused with and a 6×His tag at the C-termi |
| Immunogen Sequence: | SPVAPACDPRLLNKLLRDSH LLHSRLSQCPDVDPLSIPVL LPAVDFSLGEWKTQTEQSKA QDILGAVSLLLEGVMAARGQ LEPSCLSSLLGQLSGQVRLL LGALQGLLGTQLPLQGRTTA HKDPNALFLSLQQLLRGKVR FLLLVEGPTLCVRRTLPTTA VPSSTSQLLTLNKFPNRTSG LLETNFSVTARTAGPGLLSR LQGFRVKITPGQLNQTSRSP VQISGYLNRTHGPVNGTHG |
| Function | Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets. |
| Protein Name | ThrombopoietinC-Mpl LigandMlMegakaryocyte Colony-Stimulating FactorMegakaryocyte Growth And Development FactorMgdfMyeloproliferative Leukemia Virus Oncogene Ligand |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Thrombopoietin proteinC-Mpl Ligand proteinMl proteinMegakaryocyte Colony-Stimulating Factor proteinMegakaryocyte Growth And Development Factor proteinMgdf proteinMyeloproliferative Leukemia Virus Oncogene Ligand proteinThpo protein |
Information sourced from Uniprot.org