| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | <0.1 EU/Mu g |
| Gene Symbol: | Cd33 |
| Gene ID: | 12489 |
| Uniprot ID: | CD33_MOUSE |
| Immunogen: | Recombinant Mouse Siglec-3/CD33 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Asp18-Glu240) of mouse Siglec3/CD33 (Accession #NP_001104528.1) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | DLEFQLVAPESVTVEEGLCV HVPCSVFYPSIKLTLGPVTG SWLRKGVSLHEDSPVATSDP RQLVQKATQGRFQLLGDPQK HDCSLFIRDAQKNDTGMYFF RVVREPFVRYSYKKSQLSLH VTSLSRTPDIIIPGTLEAGY PSNLTCSVPWACEQGTPPTF SWMSTALTSLSSRTTDSSVL TFTPQPQDHGTKLTCLVTFS GAGVTVERTIQLNVTRKSGQ MRE |
| Post Translational Modifications | Glycosylated. Phosphorylation is involved in binding to PTPN6 and PTPN11. |
| Function | Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Preferentially binds sialic acid to the short O-linked glycans of certain mucins. |
| Protein Name | Myeloid Cell Surface Antigen Cd33Sialic Acid-Binding Ig-Like Lectin 3Siglec-3Cd Antigen Cd33 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Myeloid Cell Surface Antigen Cd33 proteinSialic Acid-Binding Ig-Like Lectin 3 proteinSiglec-3 proteinCd Antigen Cd33 proteinCd33 proteinSiglec3 protein |
Information sourced from Uniprot.org
