| Tissue Specificity | Highly expressed at the wound site and diminishes away from the wound. Not expressed in fibroblasts and endothelial cells in intact skin. In adult brain, expressed primarily in neurons and in resting and reactive microglia. Expressed in both neurons and microglia. Highly expressed in activated microglia in response to injury. Expressed in macrophage. |
| Post Translational Modifications | N-glycosylated. Cleaved by ELANE.proteolysis is blocked by SLPI and is concentration- and time-dependent and induces CXCL8/IL-8 production.granulin-3 and granulin-4 are resistant to ELANE. Cleaved by CTSL in lysosome thus regulating the maturation and turnover of progranulin within the lysosome. |
| Function | Secreted protein that acts as a key regulator of lysosomal function and as a growth factor involved in inflammation, wound healing and cell proliferation. Regulates protein trafficking to lysosomes, and also the activity of lysosomal enzymes. Also facilitates the acidification of lysosomes, causing degradation of mature CTSD by CTSB. In addition, functions as a wound-related growth factor that acts directly on dermal fibroblasts and endothelial cells to promote division, migration and the formation of capillary-like tubule structures. Also promotes epithelial cell proliferation by blocking TNF-mediated neutrophil activation preventing release of oxidants and proteases. Moreover, modulates inflammation in neurons by preserving neurons survival, axonal outgrowth and neuronal integrity. Granulin-3: Inhibits epithelial cell proliferation and induces epithelial cells to secrete IL-8. Granulin-7: Stabilizes CTSD through interaction with CTSD leading to maintain its aspartic-type peptidase activity. |
| Protein Name | ProgranulinPgrnAcrograninEpithelin/Granulin PrecursorGlycoprotein Of 88 KdaGp88Glycoprotein 88Pc Cell-Derived Growth FactorPcdgfProepithelinPepi Cleaved Into - Paragranulin - Granulin-1 - Granulin-2 - Granulin-3 - Granulin-4 - Granulin-5 - Granulin-6 - Granulin-7 |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | SecretedLysosomeEndocytosed By Sort1 And Delivred To LysosomesTargeted To Lysosome By Psap Via M6pr And Lrp1In Both Biosynthetic And Endocytic PathwaysCo-Localized With Gba1 In The Intracellular Trafficking Compartments Until To Lysosome |
| Alternative Protein Names | Progranulin proteinPgrn proteinAcrogranin proteinEpithelin/Granulin Precursor proteinGlycoprotein Of 88 Kda proteinGp88 proteinGlycoprotein 88 proteinPc Cell-Derived Growth Factor proteinPcdgf proteinProepithelin proteinPepi Cleaved Into - Paragranulin - Granulin-1 - Granulin-2 - Granulin-3 - Granulin-4 - Granulin-5 - Granulin-6 - Granulin-7 proteinGrn protein |
Information sourced from Uniprot.org
