Mouse Nectin-2/PVRL2/CD112 protein (Recombinant) (C-His) (STJP002800)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse Nectin-2/PVRL2/CD112 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln32-Gly351) of mouse Nectin-2/PVRL2/CD112 (Accession #NP_033016.3) fused with a 6×His tag at the C-terminus
General Information
| Short Description | Recombinant-Mouse Nectin-2/PVRL2/CD112-C-His protein was developed in hek293 cells using the region Gln32-Gly351. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | <0.1 EU/Mu g |
Target Information
| Gene Symbol | Nectin2 |
| Gene ID | 19294 |
| Uniprot ID | NECT2_MOUSE |
| Immunogen | Recombinant Mouse Nectin-2/PVRL2/CD112 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln32-Gly351) of mouse Nectin-2/PVRL2/CD112 (Accession #NP_033016.3) fused with a 6×His tag at the C-terminus |
| Immunogen Region | Gln32-Gly351 |
| Immunogen Sequence | QDVRVRVLPEVRGRLGGTVE LPCHLLPPTTERVSQVTWQR LDGTVVAAFHPSFGVDFPNS QFSKDRLSFVRARPETNADL RDATLAFRGLRVEDEGNYTC EFATFPNGTRRGVTWLRVIA QPENHAEAQEVTIGPQSVAV ARCVSTGGRPPARITWISSL GGEAKDTQEPGIQAGTVTII SRYSLVPVGRADGVKVTCRV EHESFEEPILLPVTLSVRYP PEVSISGYDDNWYLGRSEA |
Additional Info
| Function | Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive. Probable cell adhesion protein. |
| Protein Name | Nectin-2Herpes Virus Entry Mediator BHerpesvirus Entry Mediator BHvebMurine Herpes Virus Entry Protein BMhvebNectin Cell Adhesion Molecule 2Poliovirus Receptor HomologPoliovirus Receptor-Related Protein 2Cd Antigen Cd112 |
| Database Links | Reactome: R-MMU-198933Reactome: -MMU-418990Reactome: -MMU-420597 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Protein Names | Nectin-2 proteinHerpes Virus Entry Mediator B proteinHerpesvirus Entry Mediator B proteinHveb proteinMurine Herpes Virus Entry Protein B proteinMhveb proteinNectin Cell Adhesion Molecule 2 proteinPoliovirus Receptor Homolog proteinPoliovirus Receptor-Related Protein 2 proteinCd Antigen Cd112 proteinNectin2 proteinMph proteinPvr proteinPvrl2 proteinPvs protein |
Information sourced from Uniprot.org