• Mouse Lipocalin-2/NGAL/LCN2 protein (Recombinant) (C-His) (STJP001142)
  • Mouse Lipocalin-2/NGAL/LCN2 protein (Recombinant) (C-His) (STJP001142)
  • Mouse Lipocalin-2/NGAL/LCN2 protein (Recombinant) (C-His) (STJP001142)
  • Mouse Lipocalin-2/NGAL/LCN2 protein (Recombinant) (C-His) (STJP001142)

Mouse Lipocalin-2/NGAL/LCN2 protein (Recombinant) (C-His) (STJP001142)

SKU:
STJP001142

Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse Lipocalin-2/NGAL/LCN2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.
Immunoreactivity: Measured by its ability to bind Iron (III) dihydroxybenzoic acid [Fe (DHBA) 3]. The binding of Fe (DHBA) 3 results in the quenching of Trp fluorescence in recombinant mouse Lipocalin-2. Recombinant mouse Lipocalin-2 can bind >47.7 Mu M of Fe (DHBA) 3
Gene Symbol: Lcn2
Gene ID: 16819
Uniprot ID: NGAL_MOUSE
Immunogen: Recombinant Mouse Lipocalin-2/NGAL Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln21-Asn200) of mouse Lipocalin-2/NGAL (Accession #NP_032517.1) fused with an 8×His tag at the C-terminus.
Post Translational Modifications N-glycosylated.
Function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity.limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin. Can also bind siderophores from M.tuberculosis.
Protein Name Neutrophil Gelatinase-Associated Lipocalin
Ngal
Lipocalin-2
Oncogene 24p3
24p3
Sv-40-Induced 24p3 Protein
Siderocalin Lcn2
P25
Database Links Reactome: R-MMU-6798695
Reactome: -MMU-6799990
Reactome: -MMU-917937
Cellular Localisation Secreted
Cytoplasmic Granule Lumen
Cytoplasmic Vesicle Lumen
Upon Binding To The Slc22a17 (24p3r) Receptor
It Is Internalized
Releases The Bound Iron In The Acidic Lumen Of Cytoplasmic Vesicles
Alternative Protein Names Neutrophil Gelatinase-Associated Lipocalin protein
Ngal protein
Lipocalin-2 protein
Oncogene 24p3 protein
24p3 protein
Sv-40-Induced 24p3 Protein protein
Siderocalin Lcn2 protein
P25 protein
Lcn2 protein

Information sourced from Uniprot.org

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