| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen: | Recombinant Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein is expressed from Expi293 with His tag at the C-terminal.；It contains Phe31-Val988 (ITGAV) acidic tail&Gly22-Ser679 (ITGB8) basic tail. |
| Immunogen Sequence: | FNLDVESPAEYAGPEGSYFG FAVDFFEPSTSSRMFLLVGA PKANTTQPGIVEGGQVLKCE CSSSRRCQPIEFDSTGNRDY AKDDPLEFKSHQWFGASVRS KQDKILACAPLYHWRTEMKQ EREPVGTCFLQDGTKTVEYA PCRSKNIDADGQGFCQGGFS IDFTKADRVLLGGPGSFYWQ GQLISDQVAEIISKYDPNVY SIKYNNQLATRTAQAIFDDS YLGYSVAVGDFNGDGIEDF |
| Background | Deletions of the genes encoding the integrin Alpha V Beta 8 (Itgav, Itgb8) have been shown to result in abnormal vascular development in the CNS, including prenatal and perinatal hemorrhage. Other work has indicated that a major function of this integrin in vivo is to promote TGF Beta activation. |
Information sourced from Uniprot.org
