| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunogen: | Recombinant Mouse Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein is expressed from Expi293 with His tag at the C-terminal.；It contains Phe31-Val988 (ITGAV) acidic tail&Gly22-Asn706 (ITGB6) basic tail. |
| Immunogen Sequence: | FNLDVESPAEYAGPEGSYFG FAVDFFEPSTSSRMFLLVGA PKANTTQPGIVEGGQVLKCE CSSSRRCQPIEFDSTGNRDY AKDDPLEFKSHQWFGASVRS KQDKILACAPLYHWRTEMKQ EREPVGTCFLQDGTKTVEYA PCRSKNIDADGQGFCQGGFS IDFTKADRVLLGGPGSFYWQ GQLISDQVAEIISKYDPNVY SIKYNNQLATRTAQAIFDDS YLGYSVAVGDFNGDGIEDF |
| Background | ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1. |
Information sourced from Uniprot.org
