| Host: | E.coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: | Measured by its ability to inhibit IL-1 alpha-dependent proliferation in D10.G4.1 mouse helper T cells. The ED50 for this effect is 2.47-9.86 ng/mL in the presence of 3ng/mL of recombinant human IL-1 alpha, corresponding to a specific acti |
| Gene Symbol: | Il1rn |
| Gene ID: | 16181 |
| Uniprot ID: | IL1RA_MOUSE |
| Immunogen Region: | Arg27-Gln178 |
| Immunogen: | Recombinant Mouse IL-1Ra/IL-1F3/IL-1RN Protein is produced by E. coli expression system. The target protein is expressed with sequence (Arg27-Gln178) of mouse IL-1Ra/IL-1F3/IL-1RN (Accession #P25085) fused with an initial Met at the N-terminus |
| Immunogen Sequence: | CDLPQTHSLGNRRALILLAQ MGRISHFSCLKDRHDFGFPE EEFDGHQFQKTQAISVLHEM IQQTFNLFSTEDSSAAWEQS LLEKFSTELYQQLNDLEACV IQEVGVEETPLMNEDSILAV RKYFQRITLYLTEKKYSPCA WEVVRAEIMRSLSFSTNLQK RLRRKD |
| Function | Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. |
| Protein Name | Interleukin-1 Receptor Antagonist ProteinIl-1rnIl-1raIrapIl1 Inhibitor |
| Database Links | Reactome: R-MMU-9020702 |
| Cellular Localisation | Isoform 1: SecretedIsoform 2: Cytoplasm |
| Alternative Protein Names | Interleukin-1 Receptor Antagonist Protein proteinIl-1rn proteinIl-1ra proteinIrap proteinIl1 Inhibitor proteinIl1rn proteinIl-1ra protein |
Information sourced from Uniprot.org