Mouse IL-16 (Pro-Interleukin-16 Cleaved Into-Interleukin-16) Antibody Pair (STJAP00548)

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STJAP00548-50
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Host: Rabbit/Rabbit
Applications: ELISA
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This IL-16 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.
Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5.
Purification: Capture Purification: Protein A or G.
Detection Purification: Protein A or G.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Determination Method: Colormetric
Gene Symbol: Il16
Gene ID: 16170
Uniprot ID: IL16_MOUSE
Immunogen: Capture immunogen: Recombinant Mouse IL-16 protien.
Detection Immunogen: Recombinant Mouse IL-16 protien.
Sample Type: Serum, plasma and other biological fluids
Post Translational Modifications Synthesized as a chemo-attractant inactive precursor which is proteolytically cleaved by caspase-3 to yield IL-16.
Function Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane. Isoform 2 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.
Protein Name Pro-Interleukin-16 Cleaved Into - Interleukin-16
Il-16
Lymphocyte Chemoattractant Factor
Lcf
Database Links Reactome: R-MMU-449836
Cellular Localisation Secreted
Isoform 1: Cytoplasm
Colocalizes With Grin2c In Neuronal Cell Bodies And Neurites
Isoform 2: Cytoplasm
Nucleus
Alternative Antibody Pair Names Pro-Interleukin-16 Cleaved Into - Interleukin-16 antibody pair
Il-16 antibody pair
Lymphocyte Chemoattractant Factor antibody pair
Lcf antibody pair
Il16 antibody pair

Information sourced from Uniprot.org

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