Mouse IL-1 receptor type II (CD121b) protein (Recombinant) (STJP000500)

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STJP000500

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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse IL-1 receptor type II (CD121b)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose, 0.01% tween80
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Immunoreactivity: Measured in an ELISA assay. The ability of mouse IL1R2 (10ug/ml) to bind biotinylated human IL1B was determined to be 0.5 ug/ml NA
Gene Symbol: Il1r2
Gene ID: 16178
Uniprot ID: IL1R2_MOUSE
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding Mouse extracellular domain of mouse IL-1 receptor type II including a C-terminal His tag was expressed in HEK293 cells. NA
Tissue Specificity Strongly expressed in B-cells, with levels 21 times higher than IL1R1. In T-cells expressed 5 times more compared with IL1R1.
Post Translational Modifications A soluble form (sIL1R2) can also be produced by proteolytic cleavage at the cell surface (shedding) involving a metalloproteinase.
Function Non-signaling receptor for IL1A, IL1B and IL1RN. Reduces IL1B activities. Serves as a decoy receptor by competitive binding to IL1B and preventing its binding to IL1R1. Also modulates cellular response through non-signaling association with IL1RAP after binding to IL1B. IL1R2 (membrane and secreted forms) preferentially binds IL1B and poorly IL1A and IL1RN. The secreted IL1R2 recruits secreted IL1RAP with high affinity.this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors.
Protein Name Interleukin-1 Receptor Type 2
Il-1r-2
Il-1rt-2
Il-1rt2
Cd121 Antigen-Like Family Member B
Il-1 Type Ii Receptor
Interleukin-1 Receptor Beta
Il-1r-Beta
Interleukin-1 Receptor Type Ii
Cd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form
Mil-1r2
Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form
Sil-1r2
Sil-1rii
Database Links Reactome: R-MMU-9020702
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cell Membrane
Secreted
Alternative Protein Names Interleukin-1 Receptor Type 2 protein
Il-1r-2 protein
Il-1rt-2 protein
Il-1rt2 protein
Cd121 Antigen-Like Family Member B protein
Il-1 Type Ii Receptor protein
Interleukin-1 Receptor Beta protein
Il-1r-Beta protein
Interleukin-1 Receptor Type Ii protein
Cd Antigen Cd121b Cleaved Into - Interleukin-1 Receptor Type 2 - Membrane Form protein
Mil-1r2 protein
Mil-1rii - Interleukin-1 Receptor Type 2 - Soluble Form protein
Sil-1r2 protein
Sil-1rii protein
Il1r2 protein
Il-1r2 protein
Il1rb protein

Information sourced from Uniprot.org

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