Mouse IGFBP-2 (Insulin-Like Growth Factor-Binding Protein 2) Antibody Pair (STJAP00536)

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STJAP00536-50
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Short Description :This IGFBP-2 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Applications:ELISA
Host:Rabbit/Goat
Reactivity:Mouse
Note:FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Conjugation:Unconjugated/Biotin
Concentration:0.5 mg/mL
Purification:Capture Purification: Protein A or G.
Detection Purification: Antigen Affinity.
Formulation:Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.
Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5.
Storage Instruction:Store at-20°C for the long term, and avoid freeze-thaw cycles.
Determination Method:Colormetric
Gene Symbol:Igfbp2
Gene ID:16008
Uniprot ID:IBP2_MOUSE
Immunogen:Capture immunogen: Recombinant Mouse IGFBP-2 protien.
Detection Immunogen: Recombinant Mouse IGFBP-2 protien.
Sample Type:Serum, plasma and other biological fluids
Post Translational Modifications Cleaved by MMP9 leading to release of free IGF2 from IGFBP2-IGF2 complex, which contributes to enhance the motility and the growth of astrocytes. O-glycosylated.
Function Multifunctional protein that plays a critical role in regulating the availability of IGFs such as IGF1 and IGF2 to their receptors and thereby regulates IGF-mediated cellular processes including proliferation, differentiation, and apoptosis in a cell-type specific manner. Functions coordinately with receptor protein tyrosine phosphatase beta/PTPRB and the IGF1 receptor to regulate IGF1-mediated signaling by stimulating the phosphorylation of PTEN leading to its inactivation and AKT1 activation. Plays a positive role in cell migration via interaction with integrin alpha5/ITGA5 through an RGD motif. Additionally, interaction with ITGA5/ITGB1 enhances the adhesion of endothelial progenitor cells to endothelial cells. Upon mitochondrial damage, facilitates apoptosis with ITGA5 of podocytes, and then activates the phosphorylation of focal adhesion kinase (FAK)-mediated mitochondrial injury.
Protein Name Insulin-Like Growth Factor-Binding Protein 2
Ibp-2
Igf-Binding Protein 2
Igfbp-2
Migfbp-2
Database Links Reactome: R-MMU-381426
Cellular Localisation Secreted
Alternative Antibody Pair Names Insulin-Like Growth Factor-Binding Protein 2 antibody pair
Ibp-2 antibody pair
Igf-Binding Protein 2 antibody pair
Igfbp-2 antibody pair
Migfbp-2 antibody pair
Igfbp2 antibody pair
Igfbp-2 antibody pair

Information sourced from Uniprot.org

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