Mouse GRP58/PDIA3 protein (Recombinant) (His-Tag) (STJP019338)

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STJP019338
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Short Description :Recombinant-Mouse GRP58/PDIA3-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE/Enzyme Activity
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:1 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 0.1M NaCl, and 10% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Endotoxin:< 1 EU per 1ug of protein (determined by LAL method)
Immunoreactivity:Specific activity is >10 A650/cm/min/mg, obtained by measuring the increase of insulin precipitation in absorbance at 650nm resulting from the reduction of insulin.
Gene Symbol:Pdia3
Gene ID:14827
Uniprot ID:PDIA3_MOUSE
Accession Number:NP_031978
Immunogen:Mouse
Immunogen Region:25-505aa
Immunogen Sequence:MSDVLEL TDENFESRVS DTGSAGLMLV EFFAPWCGHC KRLAPEYEAA ATRLKGIVPL AKVDCTANTN TCNKYGVSGY PTLKIFRDGE EAGAYDGPRT ADGIVSHLKK QAGPASVPLR TEEEFKKFIS DKDASVVGFF RDLFSDGHSE FLKAASNLRD NYRFAHTNIE SLVKEYDDNG EGITIFRPLH LANKFEDKTV AYTEKK
Tissue Specificity In caput and cauda epididymal spermatozoa, detected in the acrosome and principal piece (at protein level).
Post Translational Modifications Phosphorylated. Within the major histocompatibility complex class I (MHC I) peptide loading complex forms reversible disulfide-linked heterodimers with TAPBP as part of its protein folding chaperone activity. This is essential to assist the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum.
Function Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity.
Protein Name Protein Disulfide-Isomerase A3
58 Kda Glucose-Regulated Protein
58 Kda Microsomal Protein
P58
Disulfide Isomerase Er-60
Endoplasmic Reticulum Resident Protein 57
Er Protein 57
Erp57
Endoplasmic Reticulum Resident Protein 60
Er Protein 60
Erp60
Database Links Reactome: R-MMU-1236974
Reactome: -MMU-901042
Reactome: -MMU-983170
Cellular Localisation Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Melanosome
Alternative Protein Names Protein Disulfide-Isomerase A3 protein
58 Kda Glucose-Regulated Protein protein
58 Kda Microsomal Protein protein
P58 protein
Disulfide Isomerase Er-60 protein
Endoplasmic Reticulum Resident Protein 57 protein
Er Protein 57 protein
Erp57 protein
Endoplasmic Reticulum Resident Protein 60 protein
Er Protein 60 protein
Erp60 protein
Pdia3 protein
Erp protein
Erp60 protein
Grp58 protein

Information sourced from Uniprot.org

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