Mouse ERAP1 protein (Recombinant) (N-His) (STJP009092)

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STJP009092
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Short Description :Recombinant-Mouse ERAP1-N-His protein was developed from e.coli for the region N-His. For use in research applications.
Applications:ELISA/Immunogen/SDS-PAGE/WB
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Dilution Range:Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Formulation:Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction:Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol:Erap1
Gene ID:80898
Uniprot ID:ERAP1_MOUSE
Immunogen:Mus musculus (Mouse)
Immunogen Region:Glu45-Asp226
Function Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Protein Name Endoplasmic Reticulum Aminopeptidase 1
Arts-1
Adipocyte-Derived Leucine Aminopeptidase
A-Lap
Aminopeptidase Pils
Puromycin-Insensitive Leucyl-Specific Aminopeptidase
Pils-Ap
Vegf-Induced Aminopeptidase
Database Links Reactome: R-MMU-983170
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Endoplasmic Reticulum Aminopeptidase 1 protein
Arts-1 protein
Adipocyte-Derived Leucine Aminopeptidase protein
A-Lap protein
Aminopeptidase Pils protein
Puromycin-Insensitive Leucyl-Specific Aminopeptidase protein
Pils-Ap protein
Vegf-Induced Aminopeptidase protein
Erap1 protein
Appils protein
Arts1 protein

Information sourced from Uniprot.org