• Mouse Ephrin-B2/EFNB2 protein (Recombinant) (C-His) (STJP001463)
  • Mouse Ephrin-B2/EFNB2 protein (Recombinant) (C-His) (STJP001463)
  • Mouse Ephrin-B2/EFNB2 protein (Recombinant) (C-His) (STJP001463)
  • Mouse Ephrin-B2/EFNB2 protein (Recombinant) (C-His) (STJP001463)

Mouse Ephrin-B2/EFNB2 protein (Recombinant) (C-His) (STJP001463)

SKU:
STJP001463

Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse Ephrin-B2/EFNB2-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Mouse EFNB2 at 1 Mu g/mL (100 Mu L/well) can bind Mouse EPHB2 with a linear range of 0.01-1.3 ng/mL.
Gene Symbol: Efnb2
Gene ID: 13642
Uniprot ID: EFNB2_MOUSE
Immunogen: Recombinant Mouse Ephrin-B2/EFNB2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Arg29-Ala232) of mouse Ephrin-B2/EFNB2 (Accession #NP_034241.2) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Inducible phosphorylation of tyrosine residues in the cytoplasmic domain.
Function Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.
Protein Name Ephrin-B2
Elf-2
Eph-Related Receptor Tyrosine Kinase Ligand 5
Lerk-5
Htk Ligand
Htk-L
Database Links Reactome: R-MMU-2682334
Reactome: -MMU-3928662
Reactome: -MMU-3928664
Reactome: -MMU-3928665
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Junction
Adherens Junction
Alternative Protein Names Ephrin-B2 protein
Elf-2 protein
Eph-Related Receptor Tyrosine Kinase Ligand 5 protein
Lerk-5 protein
Htk Ligand protein
Htk-L protein
Efnb2 protein
Elf2 protein
Epl5 protein
Eplg5 protein
Htkl protein
Lerk5 protein

Information sourced from Uniprot.org

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