Mouse CRMP1 protein (Recombinant) (His-Tag) (STJP019374)
SPECIFICATIONS
HostE.coli
ImmunogenMouse
General Information
| Short Description | Recombinant-Mouse CRMP1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.25 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.5) containing 40% Glycerol, 0.2M NaCl, 0.1mM PMSF |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Crmp1 |
| Gene ID | 12933 |
| Uniprot ID | DPYL1_MOUSE |
| Accession Number | NP_031791 |
| Immunogen | Mouse |
| Immunogen Region | 1-572aa |
| Immunogen Sequence | MGSSHHHHHH SSGLVPRGSH MGSEFMSHQG KKSIPHITSD RLLIRGGRII NDDQSFYADV YLEDGLIKQI GENLIVPGGV KTIEANGRMV IPGGIDVNTY LQKPSQGMTS ADDFFQGTKA ALAGGTTMII DHVVPEPGSS LLTSFEKWHE AADTKSCCDY SLHVDITSWY DGVREELEVL VQDKGVNSFQ VYMAYKDLYQ MSDSQLYEAF TFLKGLGAVI LVHAENGD |
Additional Info
| Post Translational Modifications | Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin. |
| Function | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis. |
| Protein Name | Dihydropyrimidinase-Related Protein 1Drp-1Collapsin Response Mediator Protein 1Crmp-1Inactive DihydropyrimidinaseUnc-33-Like Phosphoprotein 3Ulip-3 |
| Database Links | Reactome: R-MMU-399956 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleCell ProjectionGrowth ConePerikaryonAssociated With Centrosomes And The Mitotic Spindle During MetaphaseColocalizes With Flna And Tubulin In The Central Region Of Drg Neuron Growth ConeFollowing Sema3a Stimulation Of Drg NeuronsColocalizes With F-Actin |
| Alternative Protein Names | Dihydropyrimidinase-Related Protein 1 proteinDrp-1 proteinCollapsin Response Mediator Protein 1 proteinCrmp-1 proteinInactive Dihydropyrimidinase proteinUnc-33-Like Phosphoprotein 3 proteinUlip-3 proteinCrmp1 proteinDpysl1 proteinUlip3 protein |
Information sourced from Uniprot.org