| Post Translational Modifications | Phosphorylation at Ser-522 enhances CRMP1-mediated alteration of FLNA ternary structure and FLNA dissociation from F-actin. |
| Function | Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance. During the axon guidance process, acts downstream of SEMA3A to promote FLNA dissociation from F-actin which results in the rearrangement of the actin cytoskeleton and the collapse of the growth cone. Involved in invasive growth and cell migration. May participate in cytokinesis. |
| Protein Name | Dihydropyrimidinase-Related Protein 1Drp-1Collapsin Response Mediator Protein 1Crmp-1Inactive DihydropyrimidinaseUnc-33-Like Phosphoprotein 3Ulip-3 |
| Database Links | Reactome: R-MMU-399956 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleCell ProjectionGrowth ConePerikaryonAssociated With Centrosomes And The Mitotic Spindle During MetaphaseColocalizes With Flna And Tubulin In The Central Region Of Drg Neuron Growth ConeFollowing Sema3a Stimulation Of Drg NeuronsColocalizes With F-Actin |
| Alternative Protein Names | Dihydropyrimidinase-Related Protein 1 proteinDrp-1 proteinCollapsin Response Mediator Protein 1 proteinCrmp-1 proteinInactive Dihydropyrimidinase proteinUnc-33-Like Phosphoprotein 3 proteinUlip-3 proteinCrmp1 proteinDpysl1 proteinUlip3 protein |
Information sourced from Uniprot.org
