• Mouse Complement C3 protein (Recombinant) (C-His&Avi) (STJP001406)

Mouse Complement C3 protein (Recombinant) (C-His&Avi) (STJP001406)

SKU:
STJP001406

Current Stock:
Host: HEK293 cells
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse Complement C3-C-His&Avi protein was developed from hek293 cells and has a target region of C-His&Avi. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: C3
Gene ID: 12266
Uniprot ID: CO3_MOUSE
Immunogen: Recombinant Mouse Complement C3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser671-Arg748) of mouse Complement component 3 (Accession #NP_033908.2) fused with a 6×His, Avi tag at the C-terminu
Function C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. The short isoform has B-cell stimulatory activity. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2.
Protein Name Complement C3
Hse-Msf Cleaved Into - Complement C3 Beta Chain - C3-Beta-C
C3bc - Complement C3 Alpha Chain - C3a Anaphylatoxin - Acylation Stimulating Protein
Asp
C3adesarg - Complement C3b Alpha' Chain - Complement C3c Alpha' Chain Fragment 1 - Complement C3dg Fragment - Complement C3g Fragment - Complement C3d Fragment - Complement C3f Fragment - Complement C3c Alpha' Chain Fragment 2
Database Links Reactome: R-MMU-173736
Reactome: -MMU-174577
Reactome: -MMU-198933
Reactome: -MMU-375276
Reactome: -MMU-381426
Reactome: -MMU-418594
Reactome: -MMU-6798695
Reactome: -MMU-8957275
Reactome: -MMU-977606
Cellular Localisation Secreted
Alternative Protein Names Complement C3 protein
Hse-Msf Cleaved Into - Complement C3 Beta Chain - C3-Beta-C protein
C3bc - Complement C3 Alpha Chain - C3a Anaphylatoxin - Acylation Stimulating Protein protein
Asp protein
C3adesarg - Complement C3b Alpha' Chain - Complement C3c Alpha' Chain Fragment 1 - Complement C3dg Fragment - Complement C3g Fragment - Complement C3d Fragment - Complement C3f Fragment - Complement C3c Alpha' Chain Fragment 2 protein
C3 protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance