| Host: |
HEK293 cells |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse Complement C3-C-His&Avi protein was developed from hek293 cells and has a target region of C-His&Avi. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Gene Symbol: |
C3 |
| Gene ID: |
12266 |
| Uniprot ID: |
CO3_MOUSE |
| Immunogen: |
Recombinant Mouse Complement C3 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ser671-Arg748) of mouse Complement component 3 (Accession #NP_033908.2) fused with a 6×His, Avi tag at the C-terminu |
| Function | C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. The short isoform has B-cell stimulatory activity. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: Adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2. |
| Protein Name | Complement C3Hse-Msf Cleaved Into - Complement C3 Beta Chain - C3-Beta-CC3bc - Complement C3 Alpha Chain - C3a Anaphylatoxin - Acylation Stimulating ProteinAspC3adesarg - Complement C3b Alpha' Chain - Complement C3c Alpha' Chain Fragment 1 - Complement C3dg Fragment - Complement C3g Fragment - Complement C3d Fragment - Complement C3f Fragment - Complement C3c Alpha' Chain Fragment 2 |
| Database Links | Reactome: R-MMU-173736Reactome: -MMU-174577Reactome: -MMU-198933Reactome: -MMU-375276Reactome: -MMU-381426Reactome: -MMU-418594Reactome: -MMU-6798695Reactome: -MMU-8957275Reactome: -MMU-977606 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Complement C3 proteinHse-Msf Cleaved Into - Complement C3 Beta Chain - C3-Beta-C proteinC3bc - Complement C3 Alpha Chain - C3a Anaphylatoxin - Acylation Stimulating Protein proteinAsp proteinC3adesarg - Complement C3b Alpha' Chain - Complement C3c Alpha' Chain Fragment 1 - Complement C3dg Fragment - Complement C3g Fragment - Complement C3d Fragment - Complement C3f Fragment - Complement C3c Alpha' Chain Fragment 2 proteinC3 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
