Mouse CHI3L1 (Chitinase-3-Like Protein 1) Antibody Pair (STJAP00571)

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STJAP00571-50
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Host: Sheep/Sheep
Applications: ELISA
Reactivity: Mouse
Note: FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS.
Short Description : This CHI3L1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA.
Conjugation: Unconjugated/Biotin
Formulation: Capture Buffer: PBS with 0.04% Proclin 300; 50% glycerol; pH 7.5.
Detection Buffer: PBS with 0.04% Proclin 300; 1% protective protein; 50% glycerol; pH 7.5.
Purification: Capture Purification: Antigen Affinity.
Detection Purification: Antigen Affinity.
Concentration: 0.5 mg/mL
Storage Instruction: Store at-20°C for long term, and avoid freeze-thaw cycles.
Determination Method: Colormetric
Gene Symbol: Chi3l1
Gene ID: 12654
Uniprot ID: CH3L1_MOUSE
Immunogen: Capture immunogen: Recombinant Mouse CHI3L1 protien.
Detection Immunogen: Recombinant Mouse CHI3L1 protien.
Sample Type: Serum, plasma and other biological fluids
Function Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
Protein Name Chitinase-3-Like Protein 1
Brp39 Protein
Breast Regression Protein 39
Cartilage Glycoprotein 39
Cgp-39
Gp-39
Database Links Reactome: R-MMU-6798695
Cellular Localisation Secreted
Extracellular Space
Cytoplasm
Endoplasmic Reticulum
Detected In Bronchoalveolar Lavage (Bal) Fluids
Localizes Mainly To Endoplasmic Reticulum When Overexpressed In Cells
With Some Protein Also Detected Throughout The Cytoplasm
Alternative Antibody Pair Names Chitinase-3-Like Protein 1 antibody pair
Brp39 Protein antibody pair
Breast Regression Protein 39 antibody pair
Cartilage Glycoprotein 39 antibody pair
Cgp-39 antibody pair
Gp-39 antibody pair
Chi3l1 antibody pair
Brp39 antibody pair
Chil1 antibody pair

Information sourced from Uniprot.org

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