Mouse CD95/FAS protein (Recombinant-Active) (C-hFc-His) (STJP011938)

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STJP011938-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Mouse CD95/FAS-C-hFc-His protein was developed from mammalian cells and has a target region of C-hFc-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: Fas
Gene ID: 14102
Uniprot ID: TNR6_MOUSE
Immunogen Region: Gly14-Arg169
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane.
Function Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both.
Protein Name Tumor Necrosis Factor Receptor Superfamily Member 6
Apo-1 Antigen
Apoptosis-Mediating Surface Antigen Fas
Faslg Receptor
Cd Antigen Cd95
Database Links Reactome: R-MMU-3371378
Reactome: -MMU-5218900
Reactome: -MMU-69416
Reactome: -MMU-75157
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Membrane Raft
Alternative Protein Names Tumor Necrosis Factor Receptor Superfamily Member 6 protein
Apo-1 Antigen protein
Apoptosis-Mediating Surface Antigen Fas protein
Faslg Receptor protein
Cd Antigen Cd95 protein
Fas protein
Apt1 protein
Tnfrsf6 protein

Information sourced from Uniprot.org

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