| Post Translational Modifications | Palmitoylated. Palmitoylation by ZDHHC7 prevents the lysosomal degradation of FAS regulating its expression at the plasma membrane. |
| Function | Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 6Apo-1 AntigenApoptosis-Mediating Surface Antigen FasFaslg ReceptorCd Antigen Cd95 |
| Database Links | Reactome: R-MMU-3371378Reactome: -MMU-5218900Reactome: -MMU-69416Reactome: -MMU-75157 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Antibody Pair Names | Tumor Necrosis Factor Receptor Superfamily Member 6 antibody pairApo-1 Antigen antibody pairApoptosis-Mediating Surface Antigen Fas antibody pairFaslg Receptor antibody pairCd Antigen Cd95 antibody pairFas antibody pairApt1 antibody pairTnfrsf6 antibody pair |
Information sourced from Uniprot.org
