Mouse CD27 (TNFRSF7) protein (Recombinant) (STJP000538)

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STJP000538
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Host: HEK293
Note: STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse CD27 (TNFRSF7)-protein was developed from hek293. For use in research applications.
Conjugation: Unconjugated
Formulation: Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose.
Storage Instruction: Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA
Endotoxin: Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA
Immunoreactivity: The activity was tested by the ability of immobilized recombinant Mouse CD27 to bind Human CD70 with a linear range of 0.08-1 ng/ml NA
Gene Symbol: Cd27
Gene ID: 21940
Uniprot ID: CD27_MOUSE
Immunogen Region: ECD
Immunogen: Optimized DNA sequence encoding extracellular domain of Mouse CD27 including a C-terminal His tag was expressed in HEK293 cells. NA
Tissue Specificity In thymus and spleen, but not in non-lymphoid tissues. Expressed on myeloid progenitor cells.
Post Translational Modifications Phosphorylated. N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans.
Function Costimulatory immune-checkpoint receptor expressed at the surface of T-cells, NK-cells and B-cells which binds to and is activated by its ligand CD70/CD27L expressed by B-cells. The CD70-CD27 signaling pathway mediates antigen-specific T-cell activation and expansion which in turn provides immune surveillance of B-cells. Mechanistically, CD70 ligation activates the TRAF2-PTPN6 axis that subsequently inhibits LCK phosphorylation to promote phenotypic and transcriptional adaptations of T-cell memory. In addition, activation by CD70 on early progenitor cells provides a negative feedback signal to leukocyte differentiation during immune activation and thus modulates hematopoiesis. Negatively regulates the function of Th2 lymphocytes in the adipose tissue.
Protein Name Cd27 Antigen
Cd27l Receptor
T-Cell Activation Antigen Cd27
Tumor Necrosis Factor Receptor Superfamily Member 7
Cd Antigen Cd27
Database Links Reactome: R-MMU-5669034
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Cd27 Antigen protein
Cd27l Receptor protein
T-Cell Activation Antigen Cd27 protein
Tumor Necrosis Factor Receptor Superfamily Member 7 protein
Cd Antigen Cd27 protein
Cd27 protein
Tnfrsf7 protein

Information sourced from Uniprot.org

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