| Host: |
Pichia |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse CCL2/MCP-1-No tag protein was developed from pichia and has a target region of No tag. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
1.Measured by the ability to inhibit the proliferation of HUVEC (Human Umbilical Vein Endothelial Cells).The ED50 for this effect is 0.20-0.80 ng/mL.2.Measured by its ability to chemoattract THP-1 cells. The ED50 for this effect is typically 2.87-11. |
| Gene Symbol: |
Ccl2 |
| Gene ID: |
20296 |
| Uniprot ID: |
CCL2_MOUSE |
| Immunogen Region: |
Gln 24-Asn148 |
| Immunogen: |
Recombinant Mouse CCL2/MCP-1 Protein is produced by Pichia expression system. The target protein is expressed with sequence (Gln 24-Asn148) of mouse CCL2/MCP-1 (Accession #NP_035463.1) fused with no additional amino acid. |
| Function | Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. |
| Protein Name | C-C Motif Chemokine 2Monocyte Chemoattractant Protein 1Monocyte Chemotactic Protein 1Mcp-1Platelet-Derived Growth Factor-Inducible Protein JeSmall-Inducible Cytokine A2 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-C Motif Chemokine 2 proteinMonocyte Chemoattractant Protein 1 proteinMonocyte Chemotactic Protein 1 proteinMcp-1 proteinPlatelet-Derived Growth Factor-Inducible Protein Je proteinSmall-Inducible Cytokine A2 proteinCcl2 proteinJe proteinMcp1 proteinScya2 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
