Mouse CCL2/MCP-1 protein (Recombinant) (No tag) (STJP002834)

SKU:
STJP002834

Current Stock:
Host: Pichia
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Mouse CCL2/MCP-1-No tag protein was developed from pichia and has a target region of No tag. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Immunoreactivity: 1.Measured by the ability to inhibit the proliferation of HUVEC (Human Umbilical Vein Endothelial Cells).The ED50 for this effect is 0.20-0.80 ng/mL.2.Measured by its ability to chemoattract THP-1 cells. The ED50 for this effect is typically 2.87-11.
Gene Symbol: Ccl2
Gene ID: 20296
Uniprot ID: CCL2_MOUSE
Immunogen Region: Gln 24-Asn148
Immunogen: Recombinant Mouse CCL2/MCP-1 Protein is produced by Pichia expression system. The target protein is expressed with sequence (Gln 24-Asn148) of mouse CCL2/MCP-1 (Accession #NP_035463.1) fused with no additional amino acid.
Function Acts as a ligand for C-C chemokine receptor CCR2. Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions. Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B.
Protein Name C-C Motif Chemokine 2
Monocyte Chemoattractant Protein 1
Monocyte Chemotactic Protein 1
Mcp-1
Platelet-Derived Growth Factor-Inducible Protein Je
Small-Inducible Cytokine A2
Cellular Localisation Secreted
Alternative Protein Names C-C Motif Chemokine 2 protein
Monocyte Chemoattractant Protein 1 protein
Monocyte Chemotactic Protein 1 protein
Mcp-1 protein
Platelet-Derived Growth Factor-Inducible Protein Je protein
Small-Inducible Cytokine A2 protein
Ccl2 protein
Je protein
Mcp1 protein
Scya2 protein

Information sourced from Uniprot.org

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