| Host: |
HEK293 |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Mouse Cathepsin S-protein was developed from hek293. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
Lyophilised from 0.2 Mu m filtered PBS solution, pH7.2, 5% Trehalose. |
| Dilution Range: |
Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Storage Instruction: |
Can be stored in working aliquots at 2°C-8°C C for one month, or at-20°C to-70°C for 1 year. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than 0.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: |
The activity was tested by the ability to cleave a flourogenic substrate, the measured activity is 300 pmole/ug/min NA |
| Gene Symbol: |
Ctss |
| Gene ID: |
13040 |
| Uniprot ID: |
CATS_MOUSE |
| Immunogen Region: |
GLN17-ILE331 |
| Immunogen: |
Optimized DNA sequence encoding mature chain of mouse Cathepsin S-CatS (GLN17-ILE331) including a C-terminal His tag was expressed in HEK293 cells. NA |
| Tissue Specificity | Widely expressed with highest expression found in non-skeletal tissues. Relatively high levels found in skeletal tissues. Expressed in spleen, B cells, dendritic cells and macrophages. |
| Function | Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules and MHC class II antigen presentation. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L. |
| Protein Name | Cathepsin S |
| Database Links | Reactome: R-MMU-1474228Reactome: -MMU-1679131Reactome: -MMU-2022090Reactome: -MMU-2132295Reactome: -MMU-6798695 |
| Cellular Localisation | LysosomeSecretedCytoplasmic VesiclePhagosome |
| Alternative Protein Names | Cathepsin S proteinCtss proteinCats protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
