Tissue Specificity | |
Post Translational Modifications | |
Function | Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs). |
Protein Name | Actin-Related Protein 2/3 Complex Subunit 4Arp2/3 Complex 20 Kda SubunitP20-Arc |
Database Links | Reactome: R-MMU-2029482Reactome: -MMU-3928662Reactome: -MMU-5663213Reactome: -MMU-8856828 |
Cellular Localisation | CytoplasmCytoskeletonCell ProjectionNucleus |
Alternative ELISA Names | Actin-Related Protein 2/3 Complex Subunit 4 ELISA kitArp2/3 Complex 20 Kda Subunit ELISA kitP20-Arc ELISA kitArpc4 ELISA kitArc20 ELISA kit |
output | |
Information sourced from Uniprot.org