| Tissue Specificity | Seems to be expressed in the central nervous system. Isoform B, isoform C and isoform E are expressed with highest levels in brain and testis. |
| Post Translational Modifications | Phosphorylated on Ser-673 by CaMK1.enhancement of GEF activity and downstream activation of RAC1. Phosphorylated by PTK2/FAK1.this promotes interaction with RAC1. |
| Function | Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. May function as a positive regulator of apoptosis. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons. |
| Protein Name | Rho Guanine Nucleotide Exchange Factor 7Beta-PixPak-Interacting Exchange Factor BetaP85spr |
| Database Links | Reactome: R-MMU-182971Reactome: -MMU-193648Reactome: -MMU-3928664Reactome: -MMU-416482Reactome: -MMU-8980692Reactome: -MMU-9013149Reactome: -MMU-9013406Reactome: -MMU-9013420Reactome: -MMU-9013424 |
| Cellular Localisation | Cell JunctionFocal AdhesionCell ProjectionRuffleCytoplasmCell CortexLamellipodiumDetected At Cell AdhesionsA Small Proportion Is Detected At Focal Adhesions |
| Alternative ELISA Names | Rho Guanine Nucleotide Exchange Factor 7 ELISA kitBeta-Pix ELISA kitPak-Interacting Exchange Factor Beta ELISA kitP85spr ELISA kitArhgef7 ELISA kitKiaa0142 ELISA kitPak3bp ELISA kit |
| output | |
Information sourced from Uniprot.org
