Mouse Alpha-Synuclein/SNCA protein (Recombinant) (C-His) (STJP002912)
SPECIFICATIONS
HostHEK293 cells
ConjugationUnconjugated
ImmunogenRecombinant Mouse Alpha-Synuclein/SNCA Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Ala140) of mouse SNCA/Alpha-Synuclein (Accession #O55042).
General Information
| Short Description | Recombinant-Mouse Alpha-Synuclein/SNCA-C-His protein was developed in hek293 cells using the region Met1-Ala140. For use in research applications. |
| Host | HEK293 cells |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Conjugation | Unconjugated |
| Formulation | Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method | < 1 EU/Mu g |
Target Information
| Gene Symbol | Snca |
| Gene ID | 20617 |
| Uniprot ID | SYUA_MOUSE |
| Immunogen | Recombinant Mouse Alpha-Synuclein/SNCA Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Ala140) of mouse SNCA/Alpha-Synuclein (Accession #O55042). |
| Immunogen Region | Met1-Ala140 |
| Immunogen Sequence | VWEKTVNTEENVYATLGSDV NLTCQTQTVGFFVQMQWSKV TNKIDLIAVYHPQYGFYCAY GRPCESLVTFTETPENGSKW TLHLRNMSCSVSGRYECMLV LYPEGIQTKIYNLLIQTHVT ADEWNSNHTIEIEINQTLEI PCFQNSSSKISSEFTYAWSV EDNGTQETLISQNHLISNST LLKDRVKLGTDYRLHLSPVQ IFDDGRKFSCHIRVGPNKIL RSSTTVKVFAKPEIPVIVE |
Additional Info
| Tissue Specificity | Expressed in brain (at protein level). Expressed in the striatum (at protein level). Highly expressed in presynaptic terminals in the central nervous system. |
| Post Translational Modifications | Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress. Ubiquitinated. The predominant conjugate is the diubiquitinated form. Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure. |
| Function | Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Also acts as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity. |
| Protein Name | Alpha-SynucleinNon-A Beta Component Of Ad AmyloidNon-A4 Component Of Amyloid PrecursorNacp |
| Database Links | Reactome: R-MMU-9833482 |
| Cellular Localisation | CytoplasmMembraneNucleusSynapseSecretedCell ProjectionAxonMembrane-Bound In Dopaminergic NeuronsExpressed And Colocalized With Septin4 In Dopaminergic Axon TerminalsEspecially At The Varicosities |
| Alternative Protein Names | Alpha-Synuclein proteinNon-A Beta Component Of Ad Amyloid proteinNon-A4 Component Of Amyloid Precursor proteinNacp proteinSnca proteinSyn protein |
Information sourced from Uniprot.org