Name: Mouse Alpha-Synuclein/SNCA protein (Recombinant) (C-His) (STJP002912)
SKU: STJP002912
Availability: InStock

General Information
Product Properties
Target Information
Additional Info
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Host:	HEK293 cells
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Formulation:	Lyophilised from a 0.2 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:	< 1 EU/Mu g

Gene Symbol:	Snca
Gene ID:	20617
Uniprot ID:	SYUA_MOUSE
Immunogen Region:	Met1-Ala140
Immunogen:	Recombinant Mouse Alpha-Synuclein/SNCA Protein is produced by E. coli expression system. The target protein is expressed with sequence (Met1-Ala140) of mouse SNCA/Alpha-Synuclein (Accession #O55042).
Immunogen Sequence:	VWEKTVNTEENVYATLGSDV NLTCQTQTVGFFVQMQWSKV TNKIDLIAVYHPQYGFYCAY GRPCESLVTFTETPENGSKW TLHLRNMSCSVSGRYECMLV LYPEGIQTKIYNLLIQTHVT ADEWNSNHTIEIEINQTLEI PCFQNSSSKISSEFTYAWSV EDNGTQETLISQNHLISNST LLKDRVKLGTDYRLHLSPVQ IFDDGRKFSCHIRVGPNKIL RSSTTVKVFAKPEIPVIVE

Tissue Specificity	Expressed in brain (at protein level). Expressed in the striatum (at protein level). Highly expressed in presynaptic terminals in the central nervous system.
Post Translational Modifications	Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress. Ubiquitinated. The predominant conjugate is the diubiquitinated form. Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.
Function	Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Also plays a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity.
Protein Name	Alpha-Synuclein Non-A Beta Component Of Ad Amyloid Non-A4 Component Of Amyloid Precursor Nacp
Database Links	Reactome: R-MMU-9833482
Cellular Localisation	Cytoplasm Membrane Nucleus Synapse Secreted Cell Projection Axon Membrane-Bound In Dopaminergic Neurons Expressed And Colocalized With Septin4 In Dopaminergic Axon Terminals Especially At The Varicosities
Alternative Protein Names	Alpha-Synuclein protein Non-A Beta Component Of Ad Amyloid protein Non-A4 Component Of Amyloid Precursor protein Nacp protein Snca protein Syn protein

Information sourced from Uniprot.org

Model	Name	Host	Reactivity	Application
STJP002951	Human Alpha-synuclein/SNCA protein (Recombinant) (C-His) (STJP002951)	Pichia
STJE0005009	Mouse Snca (Alpha-synuclein) Sandwich ELISA Kit (STJE0005009)		Mouse	ELISA
STJP001148	Mouse TNF-alpha protein (Active Recombinant) (C-His) (STJP001148)	HEK293 cells
STJP001309	Mouse IL-1 alpha protein (Recombinant) (C-His) (STJP001309)	HEK293 cells
STJP002799	Mouse SIRP-alpha/CD172a protein (Recombinant) (C-His) (STJP002799)	HEK293 cells

Mouse Alpha-Synuclein/SNCA protein (Recombinant) (C-His) (STJP002912)

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