| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Lysosomal acid lipase Blocking Peptide for STJ507784 is synthetically produced from the 200-250 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | LIPA |
| Gene ID: | 3988 |
| Uniprot ID: | LICH_HUMAN |
| Immunogen Region: | 200-250 |
| Specificity: | This blocking peptide is recommended for use in combination with Lysosomal acid lipase antibody, STJ507784 |
| Immunogen: | Synthetic peptide corresponding to amino acids within region 200-250 on Human Lysosomal acid lipase protein. |
| Post Translational Modifications | Glycosylation is not essential for catalytic activity. |
| Function | Catalyzes the deacylation of cholesteryl ester core lipids of endocytosed low density lipoproteins to generate free fatty acids and cholesterol. Hydrolyzes triglycerides (1,2,3-triacylglycerol) and diglycerides (such as 1,2-diacylglycerol and 1,3-diacylglycerol) with preference for the acyl moieties at the sn-1 or sn-3 positions. |
| Peptide Name | Lysosomal Acid Lipase/Cholesteryl Ester Hydrolase Acid Cholesteryl Ester Hydrolase Lal Cholesteryl Esterase Diacylglycerol Lipase Lipase A Sterol Esterase Triacylglycerol Ester Hydrolase Triacylglycerol Lipase |
| Database Links | Reactome: R-HSA-8964038 |
| Cellular Localisation | Lysosome |
| Alternative Peptide Names | Lysosomal Acid Lipase/Cholesteryl Ester Hydrolase protein Acid Cholesteryl Ester Hydrolase protein Lal protein Cholesteryl Esterase protein Diacylglycerol Lipase protein Lipase A protein Sterol Esterase protein Triacylglycerol Ester Hydrolase protein Triacylglycerol Lipase protein LIPA protein |
Information sourced from Uniprot.org