LRRK1 Positive Control for STJ501638 peptide (STJ505625)

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STJ505625-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : LRRK1 Positive Control for STJ501638 is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:2, 500-1:5, 000
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: LRRK1
Gene ID: 79705
Uniprot ID: LRRK1_HUMAN
Specificity: This is positive control is recommended for use in combination with LRRK1 antibody STJ501638.
Immunogen: Purfied protein.
Post Translational Modifications Autophosphorylated. Autophosphorylation is inhibited in its dimeric state. Phosphorylated by protein kinase C isozymes PRKCA, PRKCB, PRKCG, PRKCE, PRKCZ and PRKCT at Thr-1061, Ser-1064, Ser-1074 and Thr-1075. Phosphorylation at these Ser-1064, Ser-1074 and Thr-1075 activates the kinase activity of LRRK1 to phosphorylate RAB7A.
Function Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking. Phosphorylates RAB7A.this activity is dependent on protein kinase C (PKC) activation. Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts.
Peptide Name Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1
Cellular Localisation Cytoplasm
Cell Membrane
Peripheral Membrane Protein
Alternative Peptide Names Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 protein
LRRK1 protein
KIAA1790 protein

Information sourced from Uniprot.org

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