| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | KIF14 Blocking Peptide for STJ501537 is synthetically produced from the 850-960 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | KIF14 |
| Gene ID: | 9928 |
| Uniprot ID: | KIF14_HUMAN |
| Immunogen Region: | 850-960 |
| Specificity: | This blocking peptide is recommended for use in combination with KIF14 antibody, STJ501537 |
| Immunogen: | Synthetic peptide taken within amino acid region 850-960 on human KIF14 protein. |
| Function | Microtubule motor protein that binds to microtubules with high affinity through each tubulin heterodimer and has an ATPase activity. Plays a role in many processes like cell division, cytokinesis and also in cell proliferation and apoptosis. During cytokinesis, targets to central spindle and midbody through its interaction with PRC1 and CIT respectively. Regulates cell growth through regulation of cell cycle progression and cytokinesis. During cell cycle progression acts through SCF-dependent proteasomal ubiquitin-dependent protein catabolic process which controls CDKN1B degradation, resulting in positive regulation of cyclins, including CCNE1, CCND1 and CCNB1. During late neurogenesis, regulates the cerebellar, cerebral cortex and olfactory bulb development through regulation of apoptosis, cell proliferation and cell division. Also is required for chromosome congression and alignment during mitotic cell cycle process. Regulates cell spreading, focal adhesion dynamics, and cell migration through its interaction with RADIL resulting in regulation of RAP1A-mediated inside-out integrin activation by tethering RADIL on microtubules. |
| Peptide Name | Kinesin-Like Protein Kif14 |
| Database Links | Reactome: R-HSA-5625900 Reactome: R-HSA-9696270 Reactome: R-HSA-9696273 |
| Cellular Localisation | Nucleus Cytoplasm Cytoskeleton Spindle Midbody Nuclear Localization Observed During Interphase Nuclear Localization Triggered By Entry Into Mitosis Cytoplasmic In Interphase Cytoplasmic In Metaphase Cells From Prophase To Metaphase Accumulates At The Developing Spindle Poles And Their Associated Microtubules During Anaphase Accumulates At The Spindle Midzone Localization To The Central Spindle And Midbody During Anaphase Is Dependent Upon Prc1 And Cit Presence In Cells Ready To Undergo Abscission Concentrates At The Contractile Ring |
| Alternative Peptide Names | Kinesin-Like Protein Kif14 protein KIF14 protein KIAA0042 protein |
Information sourced from Uniprot.org