• Human YKL-40/CHI3L1 protein (Recombinant) (C-His) (STJP001347)

Human YKL-40/CHI3L1 protein (Recombinant) (C-His) (STJP001347)

SKU:
STJP001347

€79.38 - €279.38
Current Stock:
Host: HEK293 cells
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Recombinant-Human YKL-40/CHI3L1-C-His protein was developed from hek293 cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Gene Symbol: CHI3L1
Gene ID: 1116
Uniprot ID: CH3L1_HUMAN
Immunogen: Recombinant Human YKL-40/CHI3L1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Tyr22-Thr383) of human YKL-40/CHI3L1 (Accession #NP_001267.2.) fused with a 6×His tag at the C-terminus.
Post Translational Modifications Glycosylated.
Function Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.
Protein Name Chitinase-3-Like Protein 1
39 Kda Synovial Protein
Cartilage Glycoprotein 39
Cgp-39
Gp-39
Hcgp-39
Ykl-40
Database Links Reactome: R-HSA-6798695
Cellular Localisation Secreted
Extracellular Space
Cytoplasm
Perinuclear Region
Endoplasmic Reticulum
Alternative Protein Names Chitinase-3-Like Protein 1 protein
39 Kda Synovial Protein protein
Cartilage Glycoprotein 39 protein
Cgp-39 protein
Gp-39 protein
Hcgp-39 protein
Ykl-40 protein
CHI3L1 protein

Information sourced from Uniprot.org

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